办公电话：027-87283955

电子邮件：lfzhu@mail.hzau.edu.cn

办公地址：作物遗传改良国家重点实验室 B410

男，教授，博士生导师。2004年毕业于华中农业大学作物遗传育种专业，获农学博士学位；2014年获聘华中农业大学教授、博士生导师。2007.12-2008.12在美国德州理工大学合作研究；2014.2-2014.5在荷兰瓦赫宁根（Wageningen）大学合作研究。2014-2017年作为中央组织部第八批援疆干部在石河子大学农学院挂职。现为作物遗传改良国家重点实验室棉花遗传改良研究团队成员，兼任湖北省棉麻学会副理事长、秘书长。2016年入选国际黄萎病咨询委员会。主要研究方向为棉花与病原分子互作及早熟多抗分子育种，已在Advanced Science, Nature Commmunications, Plant Physiology等学术期刊发表研究论文60多篇，申请或获得国家发明专利10多项。相关研究成果获得国家科技进步二等奖一项（2013）、湖北省科技进步一等奖一项（2012）、湖北省技术发明二等奖一项（2008）等多项。2016年获得湖北省杰出青年基金资助，入选科技部中青年科技创新领军人才推进计划，2018年入选国家“**计划”科技创新领军人才。

（1） 棉花木质素代谢关键因子的遗传定位与基因功能解析，国家自然科学基金，2018-2021（主持）

（2） 植物与黄萎病菌互作关键因子鉴定与应用，科技部，双边政府间科技交流项目（主持）

（3） 棉花多抗与优质种质创新及示范，科技部发展中国家科技援助项目，2018-2020（主持）

（4） 早熟耐高温棉花新品种培育，国家重点研发计划，2018-2020（主持）

（5） 基于GbWRKY1与GhPHO2研究磷稳态调控棉花生长发育与多抗的分子机制，国家自然科学基金，2015-2018（主持）

（6） 抗黄萎病棉花新种质创新与利用合作研发，国家国际科技合作专项，2015-2018（参与）

（7） SSN基因家族调控棉花抗黄萎病反应的功能解析，国家自然科学基金，2013-2016（主持）

（8） 抗黄萎病棉花种质创新与育种应用，转基因专项重点项目，2014-2016（主持）

（9） GbEIN2与GbERF1在棉花与黄萎病菌互作中的功能鉴定，国家自然科学基金，2010-2012（主持）

（10） 棉花杂种优势机理研究与应用，863，2011-2015（子课题主持）

发明专利：

（1） 朱龙付，张献龙，柳仕明.一种棉花抗枯萎病基因及其应用。专利号：201811411360.5

（2） 朱龙付，张献龙，苗玉焕.一种棉花免疫系统的激活剂及其应用。专利申请号：201810388685.X 申请日期20180427

（3） 朱龙付，张献龙，苗玉焕.棉花基因GbTSA1和GbTSB1及其在抗黄萎病中的应用。专利申请号：201810198752.1 申请日期20180312

（4） 张献龙，朱龙付，胡琴，李南南.调控棉花黄萎病抗性的棉花钙依赖蛋白激酶GhCPK33基因及应用。专利申请号：201810147454.X 申请日期 20180112

（5） 朱龙付；闵玲；李耀耀；张献龙. 两个花药发育特异启动子及应用，专利号： 201610481110.3

（6） 朱龙付，张献龙，高巍，龙璐.棉花同源结构域转录因子基因GbHDTF1及应用.专利授权号：ZL201310345168.1 申请日20130809授权公告20150422

（7） 张献龙，朱龙付，闵玲，胡琴.介导棉花广谱抗性的棉花Lac1基因及应用.专利授权号：ZL201310109621.9 申请日20130329授权公告20150401

（8） 朱龙付，高巍，龙璐，张献龙，聂以春，袁道军.棉花硬脂酰去饱和化酶GbSSI2基因及应用.专利授权号：ZL201310019959.5 申请日20130118授权公告20150304

（9） 张献龙，朱龙付，孙龙清.一种棉花细胞色素P450基因及应用.专利授权号：ZL201210084887.8 申请日20120328授权公告20150304

（10） 张献龙，朱龙付，徐理.一种棉花WRKY类转录因子及应用.专利申请号：201110432296.0

（11） 张献龙，朱龙付，闵玲.　一种棉花酪蛋白激酶基因及其应用.专利申请号：201110231724.3

（12） 张献龙，朱龙付，涂礼莉，聂以春，郭小平，曾范昌，刘迪秋.从棉花组织中抽提RNA的方法.专利授权号:ZL 2004 1 0060637.6

获得奖励：

（1） 张献龙，聂以春、朱龙付，郭小平，卢怀玉，刘立清，林忠旭，涂礼莉，杨国正，金双侠.棉花种质创新与强优势杂交棉新品种培育与应用. 国家科技进步奖二等奖，2013

（2） 张献龙，聂以春，朱龙付，林忠旭，郭小平，卢怀玉，杨国正，余宏章，涂礼莉.强优势多抗杂交棉新品种“华杂棉H318”的选育与应用. 湖北省科技进步奖一等奖，2012

（3） 张献龙，林忠旭，朱龙付，涂礼莉，金双侠，郭小平. 棉花分子育种技术体系建立与应用.湖北省技术发明奖二等奖，2008

教学研究与教学改革：

（1） 华中农业大学第10届青年教师讲课竞赛二等奖，2011年

（2） 华中农业大学教学质量优秀二等奖，2011年，2020年

2021-2020年

1. Liu, S., X. Zhang, S. Xiao, J. Ma, W. Shi, T. Qin, H. Xi, X. Nie, C. You, Z. Xu, T. Wang, Y. Wang, Z. Zhang, J. Li, J. Kong, A. Aierxi, Y. Yu, K. Lindsey, S. J. Klosterman, X. Zhang and L. Zhu (2021). A Single-Nucleotide Mutation in a GLUTAMATE RECEPTOR-LIKE Gene Confers Resistance to Fusarium Wilt in Gossypium hirsutum. Advanced Science n/a(n/a): 2002723.

2. Yizan Ma, L. M., Junduo Wang, Yaoyao Li, Yuanlong Wu, Qin Hu, Yuanhao Ding,, Y. L. Maojun Wang, Zhaolong Gong, Sai Xie, Xiaojun Su, Chaozhi Wang, Yunlong, Q. F. Zhao, Yanlong Li, Huabin Chi, Miao Chen, Aamir Hamid Khan, Keith Lindsey, and X. L. Longfu Zhu, Xianlong (2021). Combined transcriptome GWAS and TWAS reveal genetic elements leading to male sterility during high temperature stress in cotton. New Phytol.

3. Hui Xi, X. Z., Zheng Qu, Dingyi Yang, Muna Alariqi, Zhaoguang Yang, Xinhui Nie, Longfu Zhu (2021). Effects of cotton-maize rotation on soil microbiome structure. Molecular Plant Pathology.

4. Luo, X., Z. Li, S. Xiao, Z. Ye, X. Nie, X. Zhang, J. Kong and L. Zhu (2021). Phosphate deficiency enhances cotton resistance to Verticillium dahliae through activating jasmonic acid biosynthesis and phenylpropanoid pathway. Plant Sci 302: 110724.

5. He, X., X. Luo, T. Wang, S. Liu, X. Zhang and L. Zhu (2020). GhHB12 negatively regulates abiotic stress tolerance in Arabidopsis and cotton. Environmental and Experimental Botany 176: 104087.

6. Luo, X., C. Li, X. He, X. Zhang and L. Zhu (2020). ABA signaling is negatively regulated by GbWRKY1 through JAZ1 and ABI1 to affect salt and drought tolerance. Plant Cell Reports 39(2): 181-194.

7. 惠慧, 张学坤, 杨定宜, 赵建军, 沈吉丽, 杨兆光, 尤春源, 聂新辉 and 朱龙付 (2020). "新疆棉花黄萎病菌的培养特性及致病力分化." 植物病理学报.

8. 沈吉丽, 肖., 惠慧, 努日曼古丽·艾尼, 胡琴, 张晓君, 杨兆光, 聂新辉, 朱龙付 (2020). "GhMYB43负调控木质素的生物合成和茉莉酸信号." 棉花学报 32(6): 522-537.

2018-2019年

1. He, X., Wang, T., Zhu, W., Wang, Y., and Zhu, L. (2018a). GhHB12, a HD-ZIP I Transcription Factor, Negatively Regulates the Cotton Resistance to Verticillium dahliae. Int J Mol Sci 19, 3997.

2. He, X., Wang, T., Xu, Z., Liu, N., Wang, L., Hu, Q., Luo, X., Zhang, X., and Zhu, L. (2018b). The cotton HD-Zip transcription factor GhHB12 regulates flowering time and plant architecture via the GhmiR157-GhSPL pathway. Communications Biology 1, 229.

3. He, X., Zhu, L., Wassan, G.M., Wang, Y., Miao, Y., Shaban, M., Hu, H., Sun, H., and Zhang, X. (2018c). GhJAZ2 attenuates cotton resistance to biotic stresses via the inhibition of the transcriptional activity of GhbHLH171. Mol Plant Pathol 19, 896-908.

4. Hu, Q., Zhu, L., Zhang, X., Guan, Q., Xiao, S., Min, L., and Zhang, X. (2018a). GhCPK33 Negatively Regulates Defense against Verticillium dahliae by Phosphorylating GhOPR3. Plant Physiol 178, 876-889.

5. Hu, Q., Min, L., Yang, X., Jin, S., Zhang, L., Li, Y., Ma, Y., Qi, X., Li, D., Liu, H., Lindsey, K., Zhu, L., and Zhang, X. (2018b). Laccase GhLac1 Modulates Broad-Spectrum Biotic Stress Tolerance via Manipulating Phenylpropanoid Pathway and Jasmonic Acid Synthesis. Plant Physiol 176, 1808-1823.

6. Li, Y., Min, L., Zhang, L., Hu, Q., Wu, Y., Li, J., Xie, S., Ma, Y., Zhang, X., and Zhu, L. (2018). Promoters of Arabidopsis Casein kinase I-like 2 and 7 confer specific high-temperature response in anther. Plant Mol Biol 98, 33-49.

7. Miao, Y., Xu, L., He, X., Zhang, L., Shaban, M., Zhang, X., and Zhu, L. (2019). Suppression of tryptophan synthase activates cotton immunity by triggering cell death via promoting SA synthesis. Plant J.

8. Shaban, M., Ahmed, M.M., Sun, H., Ullah, A., and Zhu, L. (2018a). Genome-wide identification of lipoxygenase gene family in cotton and functional characterization in response to abiotic stresses. BMC Genomics 19, 599.

9. Shaban, M., Miao, Y., Ullah, A., Khan, A.Q., Menghwar, H., Khan, A.H., Ahmed, M.M., Tabassum, M.A., and Zhu, L. (2018b). Physiological and molecular mechanism of defense in cotton against Verticillium dahliae. Plant Physiol Biochem 125, 193-204.

10. Song, Y., Liu, L., Wang, Y., Valkenburg, D.J., Zhang, X., Zhu, L., and Thomma, B. (2018). Transfer of tomato immune receptor Ve1 confers Ave1-dependent Verticillium resistance in tobacco and cotton. Plant Biotechnol J 16, 638-648.

11. Wang, M., Tu, L., Yuan, D., Zhu, Shen, C., Li, J., Liu, F., Pei, L., Wang, P., Zhao, G., Ye, Z., Huang, H., Yan, F., Ma, Y., Zhang, L., Liu, M., You, J., Yang, Y., Liu, Z., Huang, F., Li, B., Qiu, P., Zhang, Q., Zhu, L., Jin, S., Yang, X., Min, L., Li, G., Chen, L.L., Zheng, H., Lindsey, K., Lin, Z., Udall, J.A., and Zhang, X. (2018). Reference genome sequences of two cultivated allotetraploid cottons, Gossypium hirsutum and Gossypium barbadense. Nat Genet.

12. Zhang, L., Wang, M., Li, N., Wang, H., Qiu, P., Pei, L., Xu, Z., Wang, T., Gao, E., Liu, J., Liu, S., Hu, Q., Miao, Y., Lindsey, K., Tu, L., Zhu, L., and Zhang, X. (2018). Long noncoding RNAs involve in resistance to Verticillium dahliae, a fungal disease in cotton. Plant Biotechnol J 16, 1172-1185.

13. Zhou, Y., Sun, L., Wassan, G.M., He, X., Shaban, M., Zhang, L., Zhu, L., and Zhang, X. (2019). GbSOBIR1 confers Verticillium wilt resistance by phosphorylating the transcriptional factor GbbHLH171 in Gossypium barbadense. Plant Biotechnol J 17, 152-163.

14. Zhu, W., Gao, E., Shaban, M., Wang, Y., Wang, H., Nie, X., and Zhu, L. (2018). GhUMC1, a blue copper-binding protein, regulates lignin synthesis and cotton immune response. Biochem Biophys Res Commun 504, 75-81.

2015-2017年

1. Ding, Y., Ma, Y., Liu, N., Xu, J., Hu, Q., Li, Y., Wu, Y., Xie, S., Zhu, L., Min, L., and Zhang, X. (2017). microRNAs involved in auxin signalling modulate male sterility under high-temperature stress in cotton (Gossypium hirsutum). Plant J 91, 977-994.

2. Gao, W., Long, L., Xu, L., Lindsey, K., Zhang, X., and Zhu, L. (2016). Suppression of the homeobox gene HDTF1 enhances resistance to Verticillium dahliae and Botrytis cinerea in cotton. Journal of Integrative Plant Biology 58, 503-513.

3. Guo, W., Jin, L., Miao, Y., He, X., Hu, Q., Guo, K., Zhu, L., and Zhang, X. (2016). An ethylene response-related factor, GbERF1-like, from Gossypium barbadense improves resistance to Verticillium dahliae via activating lignin synthesis. Plant Mol Biol 91, 305-318.

4. He, X., Zhu, L., Xu, L., Guo, W., and Zhang, X. (2016). GhATAF1, a NAC transcription factor, confers abiotic and biotic stress responses by regulating phytohormonal signaling networks. Plant Cell Rep 35, 2167-2179.

5. Hu, H., He, X., Tu, L., Zhu, L., Zhu, S., Ge, Z., and Zhang, X. (2016). GhJAZ2 negatively regulates cotton fiber initiation by interacting with the R2R3-MYB transcription factor GhMYB25-like. Plant J 88, 921-935.

6. Min, L., Hu, Q., Li, Y., Xu, J., Ma, Y., Zhu, L., Yang, X., and Zhang, X. (2015). LEAFY COTYLEDON1-CASEIN KINASE I-TCP15-PHYTOCHROME INTERACTING FACTOR4 Network Regulates Somatic Embryogenesis by Regulating Auxin Homeostasis. Plant Physiol 169, 2805-2821.

7. Wang, M., Tu, L., Lin, M., Lin, Z., Wang, P., Yang, Q., Ye, Z., Shen, C., Li, J., Zhang, L., Zhou, X., Nie, X., Li, Z., Guo, K., Ma, Y., Huang, C., Jin, S., Zhu, L., Yang, X., Min, L., Yuan, D., Zhang, Q., Lindsey, K., and Zhang, X. (2017). Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication. Nat Genet 49, 579-587.

8. Wu, Y., Min, L., Wu, Z., Yang, L., Zhu, L., Yang, X., Yuan, D., Guo, X., and Zhang, X. (2015). Defective pollen wall contributes to male sterility in the male sterile line 1355A of cotton. Scientific reports 5, 9608.

9. Yuan, D., Tang, Z., Wang, M., Gao, W., Tu, L., Jin, X., Chen, L., He, Y., Zhang, L., Zhu, L., Li, Y., Liang, Q., Lin, Z., Yang, X., Liu, N., Jin, S., Lei, Y., Ding, Y., Li, G., Ruan, X., Ruan, Y., and Zhang, X. (2015). The genome sequence of Sea-Island cotton (Gossypium barbadense) provides insights into the allopolyploidization and development of superior spinnable fibres. Scientific reports 5, 17662.

2012-2014年

1. Gao, W., Long, L., Zhu, L.F., Xu, L., Gao, W.H., Sun, L.Q., Liu, L.L., and Zhang, X.L. (2013). Proteomic and virus-induced gene silencing (VIGS) Analyses reveal that gossypol, brassinosteroids, and jasmonic acid contribute to the resistance of cotton to Verticillium dahliae. Mol Cell Proteomics 12, 3690-3703.

2. He, L., Yang, X., Wang, L., Zhu, L., Zhou, T., Deng, J., and Zhang, X. (2013). Molecular cloning and functional characterization of a novel cotton CBL-interacting protein kinase gene (GhCIPK6) reveals its involvement in multiple abiotic stress tolerance in transgenic plants. Biochem Biophys Res Commun 435, 209-215.

3. Li, C., He, X., Luo, X., Xu, L., Liu, L., Min, L., Jin, L., Zhu, L., and Zhang, X. (2014). Cotton WRKY1 Mediates the Plant Defense-to-Development Transition during Infection of Cotton by Verticillium dahliae by Activating JASMONATE ZIM-DOMAIN1 Expression. Plant Physiology 166, 2179-2194.

4. Liu, G., Li, X., Jin, S., Liu, X., Zhu, L., Nie, Y., and Zhang, X. (2014a). Overexpression of rice NAC gene SNAC1 improves drought and salt tolerance by enhancing root development and reducing transpiration rate in transgenic cotton. PLoS One 9, e86895.

5. Liu, L., Zhang, W., Zhou, Y., Miao, Y., Xu, L., Liu, M., Zhang, K., Zhang, X., and Zhu, L. (2014b). The resistance of cotton and tomato to Verticillium dahliae from cotton is independent on Ve1. SCIENTIA SINICA Vitae 44, 803-814.

6. Long, L., Gao, W., Xu, L., Liu, M., Luo, X., He, X., Yang, X., Zhang, X., and Zhu, L. (2014). GbMPK3, a mitogen-activated protein kinase from cotton, enhances drought and oxidative stress tolerance in tobacco. Plant Cell Tiss Organ Cult 116, 153-162.

7. Min, L., Zhu, L., Tu, L., Deng, F., Yuan, D., and Zhang, X. (2013). Cotton GhCKI disrupts normal male reproduction by delaying tapetum programmed cell death via inactivating starch synthase. Plant J 75, 823-835.

8. Min, L., Li, Y., Hu, Q., Zhu, L., Gao, W., Wu, Y., Ding, Y., Liu, S., Yang, X., and Zhang, X. (2014). Sugar and Auxin Signaling Pathways Respond to High-Temperature Stress during Anther Development as Revealed by Transcript Profiling Analysis in Cotton. Plant Physiology 164, 1293-1308.

9. Sun, L., Zhu, L., Xu, L., Yuan, D., Min, L., and Zhang, X. (2014). Cotton cytochrome P450 CYP82D regulates systemic cell death by modulating the octadecanoid pathway. Nat Commun 5, 5372.

10. Wang, Y., Jin, S., Wang, M., Zhu, L., and Zhang, X. (2013). Isolation and characterization of a conserved domain in the eremophyte H+-PPase family. PLoS One 8, e70099.

11. Xu, L., Zhu, L.-F., and Zhang, X.-L. (2012a). Research on Resistance Mechanism of Cotton to Verticillium Wilt. Acta Agron Sin 38, 1553-1560.

12. Xu, L., Jin, L., Long, L., Liu, L., He, X., Gao, W., Zhu, L., and Zhang, X. (2012b). Overexpression of GbWRKY1 positively regulates the Pi starvation response by alteration of auxin sensitivity in Arabidopsis. Plant Cell Rep 31, 2177-2188.

13. Xu, L., Zahid, K.R., He, L., Zhang, W., He, X., Zhang, X., Yang, X., and Zhu, L. (2013). GhCAX3 gene, a novel Ca(2+)/H(+) exchanger from cotton, confers regulation of cold response and ABA induced signal transduction. PLoS One 8, e66303.

14. Xu, L., Zhang, W., He, X., Liu, M., Zhang, K., Shaban, M., Sun, L., Zhu, J., Luo, Y., Yuan, D., Zhang, X., and Zhu, L. (2014). Functional characterization of cotton genes responsive to Verticillium dahliae through bioinformatics and reverse genetics strategies. J Exp Bot 65, 6679-6692.

2011年及以前

1. Li, Y., Liu, D., Tu, L., Zhang, X., Wang, L., Zhu, L., Tan, J., and Deng, F. (2010). Suppression of GhAGP4 gene expression repressed the initiation and elongation of cotton fiber. Plant Cell Rep 29, 193-202.

2. Liu, D., Tu, L., Wang, L., Li, Y., Zhu, L., and Zhang, X. (2008). Characterization and expression of plasma and tonoplast membrane aquaporins in elongating cotton fibers. Plant Cell Rep 27, 1385-1394.

3. Pasapula, V., Shen, G., Kuppu, S., Paez-Valencia, J., Mendoza, M., Hou, P., Chen, J., Qiu, X., Zhu, L., Zhang, X., Auld, D., Blumwald, E., Zhang, H., Gaxiola, R., and Payton, P. (2011). Expression of an Arabidopsis vacuolar H+-pyrophosphatase gene (AVP1) in cotton improves drought- and salt tolerance and increases fibre yield in the field conditions. Plant Biotechnology Journal 9, 88-99.

4. Xu, L., Zhu, L., Tu, L., Guo, X., Long, L., Sun, L., Gao, W., and Zhang, X. (2011a). Differential Gene Expression in Cotton Defence Response to Verticillium dahliae by SSH. Journal of Phytopathology 159, 606-615.

5. Xu, L., Zhu, L., Tu, L., Liu, L., Yuan, D., Jin, L., Long, L., and Zhang, X. (2011b). Lignin metabolism has a central role in the resistance of cotton to the wilt fungus Verticillium dahliae as revealed by RNA-Seq-dependent transcriptional analysis and histochemistry. J Exp Bot 62, 5607-5621.

6. Yang, X., Tu, L., Zhu, L., Fu, L., Min, L., and Zhang, X. (2008). Expression profile analysis of genes involved in cell wall regeneration during protoplast culture in cotton by suppression subtractive hybridization and macroarray. Journal of Experimental Botany 59, 3661-3674.

7. Zeng, F., Zhang, X., Zhu, L., Tu, L., Guo, X., and Nie, Y. (2006). Isolation and Characterization of Genes Associated to Cotton Somatic Embryogenesis by Suppression Subtractive Hybridization and Macroarray*. Plant Molecular Biology 60, 167-183.

8. Zeng, F., Zhang, X., Cheng, L., Hu, L., Zhu, L., Cao, J., and Guo, X. (2007). A draft gene regulatory network for cellular totipotency reprogramming during plant somatic embryogenesis. Genomics 90, 620-628.

9. Zhu, L.-f., He, X., Yuan, D.-j., Xu, L., Xu, L., Tu, L.-l., Shen, G.-x., Zhang, H., and Zhang, X.-l. (2011). Genome-Wide Identification of Genes Responsive to ABA and Cold/Salt Stresses in Gossypium hirsutum by Data-Mining and Expression Pattern Analysis. Agricultural Sciences in China 10, 499-508.

10. Zhu, L., Tu, L., Zeng, F., Liu, D., and Zhang, X. (2005a). An improved simple protocol for isolation of high quality RNA from Gossypium spp. suitable for cDNA library construction. Acta Agronomic Sinica 31, 1657-1659.

11. Zhu, L., Tu, L., Zhang, X., Nie, Y., Guo, X., and Xia, Q. (2005b). Construction and Analysis of SSH Library of Gossypium barbadense upon Infection with Verticillium dahliae. Acta Genetica Sinica 32, 528-532.

12. 曹景林, 朱龙付, 谭家福, 邓锋林, 李允静, 郝娟, 徐士成, and 张献龙. (2009). 适用于蛋白质双向电泳的棉花胚性培养物蛋白质提取技术. 棉花学报 21, 3-9.

13. 宋俊乔, 孙培均, 张霞, 张献龙, 聂以春, 郭小平, and 朱龙付. (2010). 棉仁高油分材料筛选及其脂肪酸发育分析. 棉花学报 22, 291-296.

14. 涂礼莉, 张献龙, 朱龙付, 聂以春, and 郭小平. (2003). 海岛棉NBS类型抗病基因类似物的起源、多样性及进化. 遗传学报 30, 1071-1077.

15. 朱龙付, and 张献龙. (2004). RNAi及其在植物遗传改良中的应用. 华中农业大学学报 23, 472-477.

16. 朱龙付, 张献龙, and 聂以春. (2003). 利用RAPD和SSR标记分析陆地棉种质资源的遗传多样性. 农业生物技术学报 11, 450-455.

17. 朱龙付, 张献龙, 聂以春, and 吴家和. (2002). 转基因抗虫棉品种(系)的遗传多样性初步研究. 华中农业大学学报 21, 401-405.