张静柏，女，1979年生，博士，华中农业大学植物科学技术学院教师。2008年1月获农学博士学位，毕业留校任教，承担《农业植物病理学》、《农业植物病理学实验》、《植物病害流行学》、《植物病理学》等课程教学。2017年6月-2018年6月在美国麻省大学阿默斯特分校进行访学研究。主要从事赤霉菌分子生物学、赤霉菌及其毒素分析检测、小麦抗赤霉菌及毒素分子育种等方面研究，主持相关国家重点研发计划项目子课题、国家自然基金青年科学基金、教育部高等学校博士学科点专项新教师基金、武汉市科技攻关计划项目，曾作为主要参与者完成国家973计划、国家重大科技专项-转基因新品种培育、中德国际合作重点项目多个国家课题，共计发表研究论文50余篇（SCI论文40余篇），授权或申请专利18项，其中国际专利1项。

1. 科技部，国家重点研发计划子课题，小麦应答DON毒素关键基因的鉴定，项目年限：2022-2026，（主持）

2. 鄂尔多斯市科学技术局，科技兴蒙”行动重点专项项目子课题，玉米收获、加工贮藏技术研发及产业化，项目年限：2022-2025，（主持）

3. 湖北省支持种业高质量发展资金项目，“旱粮作物优异种质资源挖掘创制及新品种培育”项目，子课题“小麦抗赤霉病高产稳产新品种选育”，项目年限：2023-2026，（参加）

4. 湖北洪山实验室，洪山实验室2022年度重大项目，小麦赤霉病绿色防控新途径，项目年限：2022-2025，（参加）

5. 科技部，国家重点研发计划，湖北麦区小麦化肥农药增效减施技术集成研究与示范，项目年限：2018-2020，（参加）

6. 科技部，国家重大科技专项，抗赤霉病转基因小麦新品系培育，项目年限：2016-2020，（参加）

7. 农业部，国家科技重大专项转基因生物新品种培育项目，高抗赤霉病和毒素转基因小麦新品种培育，项目年限：2014-2016，（参加）

8. 国家自然科学基金青年科学基金项目，赤霉菌致病相关基因CR1 的鉴定和功能分析，项目年限：2013-2015，（主持）

部分发明专利：

1. 何伟杰，张静柏，廖玉才，郑梦茹，张愉姗，黄涛. 镰刀菌毒素降解酶基因DONepi、DONrd 及其应用. 申请号：202511815390.2，申请时间：2025.12.4

2. 何伟杰，张静柏，廖玉才，张甜甜，郑梦茹，张愉姗，黄涛. 完全降解 DON的类诺卡氏菌 N25 及其在镰刀菌毒素降解中的应用. 申请号：202511815375.8，申请时间：2025.12.4

3. 廖玉才，何伟杰，李和平，张静柏. 脱亚硫酸杆菌PGC-3-9及其在镰刀菌毒素脱毒中的应用. ZL 202010446781.2 授权时间：2023.8.4

4. 廖玉才，何伟杰，李和平，易沭远，张静柏，黄涛. 镰刀菌毒素脱毒路径相关基因ADH、AKR6D1、AKR13B2及其应用. 授权日：2020.08.11

5. Liao, Y.-C., Li, H.-P., Zhang, J.-B., Huang, T., Song, X.-S., Cheng, W., Yang, P. Fusarium chitin synthase gene Chs3b and the use thereof. 授权日：2019.07.16

6. 廖玉才，李和平，张静柏，杨鹏. 一种禾谷镰刀菌葡聚糖合成酶基因GLS及应用. 授权日：2019.12.13

7. 廖玉才，宫安东，李和平，张静柏. 防治作物储藏期黄曲霉菌及毒素的海藻希瓦氏菌及其应用. 授权日：2018.04.10

8. 廖玉才，宫安东，李和平，张静柏. 一株防治小麦赤霉病的解淀粉芽孢杆菌及其应用. 授权日：2017.08.15

9. 廖玉才，李和平，胡祖权，张静柏. 抗伏马菌素B1的单克隆重组抗体H2.授权日：2015.01.28

10. 廖玉才，李和平，胡祖权，张静柏. 抗伏马菌素B1的单克隆重组抗体H7. 授权日：2015.01.28

获得奖励：

2025年湖北省第四届微生物培养皿艺术设计大赛优秀指导教师

2023年国家级线上一流本科课程《农业植物病理学》（参加）

2021年度华中农业大学教学质量三等奖

2014年获得华中农业大学教学质量三等奖

学术论文与著作（*表示通讯作者，#表示共同作者）：

部分学术论文

第一作者或通讯作者文章

1. He, W.-J., Xiong, R.-Y. Zheng, M.-R., Zhang, T.-T., Zhang, Y.-S., Wang, Q., Zhao, C.-X., Huang, T., Liu, Y.-K., Tian, Y., Tabl, K.-M., Mao, X.-M., Li, P., Feng, G.-W.,  Bai, X.-C., Liu, Q., Yan, W.-H., Liao, Y.-C., Zhang, J.-B*., Yin, P*., Wu, A.-B*. Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol. Nature Communications, 2026, 17: 3240.

2. He, W.-J., Yang, P., Huang, T., Liu, Y.-F., Zhang, Y.-W., Zhang, W.-M., Zhang, T.-T., Zheng, M.-R., Ma, L., Zhao, C.-X., Li, H.-P., Liao, Y.-C., Wu, A.-B., Zhang, J.-B*. Detoxifying bacterial genes for deoxynivalenol epimerization confer durable resistance to Fusarium head blight in wheat. Plant Biotechnology Journal, 2024, 22(9): 2395-2409.

3. He, W.-J., Zhang T.-T., Zheng, M.-R., Tabl, K.-M., Huang T, Liao, Y.-C., Wu, A.-B., Zhang, J.-B*. Utilization of a novel soil-isolated strain Devosia insulae FS10-7 for deoxynivalenol degradation and biocontrol of Fusarium crown rot in wheat. Phytopathology, 2024, 114(5): 1057-1067.

4. Gong A.-D., Lei Y.-Y., He W.-J., Liao Y.-C., Ma L., Zhang T.-T., Zhang J.-B*. The inhibitory effect of Pseudomonas stutzeri YM6 on Aspergillus flavus growth and aflatoxins production by the production of volatile dimethyl trisulfide. Toxins, 2022, 14(11): 788.

5. Shang G.-F., Li S.-Q., Yu H., Yang J., Li S.-M., Yu Y.-Q., Wang J.-M, Wang Y., Zeng Z*., Zhang J.-B*., Hu Z.-Q*. An efficient strategy combining immunoassays and molecular identification for the investigation of Fusarium infections in ear rot of maize in Guizhou province, China. Frontiers in Microbiology, 2022, 13: 849698.

6. Yang, P., Yi, S.-Y., Nian, J.-N., Yuan, Q.-S., He, W.-J., Zhang, J.-B*., Liao, Y.-C*. Application of double-strand RNAs targeting chitin synthase, glucan synthase, and protein Kinase reduces Fusarium graminearum spreading in wheat. Frontiers in Microbiology, 2021, 12: 660976.

7. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Zhao, Y., Wu, A.-B., Dong, W.-B., Li, H.-P., Zhang, J.-B*., Liao, Y.-C*. A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain. Food Chemistry, 2020, 321: 126703.

8. He, W.-J., Shi, M.-M., Yang, P., Huang, T., Yuan, Q.-S., Yi, S.-Y., Wu, A.-B., Li H.-P., Gao C.-B., Zhang J.-B*., Liao Y.-C*. Novel soil bacterium strain Desulfitobacterium sp. PGC-3-9 detoxifies trichothecene mycotoxins in wheat via de-epoxidation under aerobic and anaerobic conditions. Toxins, 2020, 12(6): 363.

9. Gong, A.-D., Sun, G.-J., Zhao, Z.-Y., Liao, Y.-C., Zhang, J.-B*. Staphylococcus saprophyticus L-38 produces volatile, 3-dimethyl-1,2-epoxybutane with strong inhibitory activity against Aspergillus flavus germination and aflatoxin production. World Mycotoxin Journal, 2020: 13 (2): 247-258.

10. Hu, Z.-Q., Li, H.-P., Liu, J.-L., Xue, S., Gong, A.-D., Zhang, J.-B*., Liao, Y.-C. Production of a phage-displayed mouse scFv antibody against Fumonisin B1 and molecular docking analysis of their interactions. Biotechnology and Bioprocess Engineering, 2016, 21: 134-143.

11. Wang, J.-H. #, Zhang, J.-B.#, Li, H.-P., Gong, A.-D., Liao, Y.-C. Molecular identification, mycotoxin production and comparative pathogenicity of Fusarium temperatum isolated from maize in China . Journal of Phytopathology, 2014, 162: 147-157.

12. Zhang, J.-B., Wang, J.-H., Gong, A.-D., Chen, F.-F., Song, B., Li, H.-P., Li, X., Peng, C.-H., Liao Y.-C*. Natural occurrence of Fusarium head blight, mycotoxins, and mycotoxin-producing strains of Fusarium in commercial fields of wheat in Hubei. Plant Pathology, 2013, 62: 92-102.

13. Li, X.#, Zhang, J.-B.#, Song, B., Li, H.-P., Xu, H. Q., Qu, B., Dang, F.-J., Liao, Y.-C*. Resistance to Fusarium head blight and seedling blight in wheat is associated with activation of a cytochrome P450 gene. Phytopathology, 2010, 100:183-191.

14. Li, H.-P. #, Zhang, J.-B.#, Shi, R.-P., Huang, T., Fischer, R., Liao, Y.-C. Engineering Fusarium head blight resistance in wheat by expression of a fusion protein containing a Fusarium-specific antibody and an antifungal peptide. Molecular Plant-Microbe Interaction, 2008, 21:1242-1248.

15. Zhang, J.-B., Li, H.-P., Dang, F.-J., Qu, B., Xu, Y.-B., Zhao, C.-S., Liao, Y.-C. Determination of the trichothecene mycotoxin chemotypes and associated geographical distribution and phylogenetic species of the Fusarium graminearum clade from China. Mycological Research, 2007, 111:967-975.

16. 胡祖权，李和平，刘锦龙，吴平，廖玉才，张静柏*. 抗伏马菌素B1单克隆重组抗体的筛选. 基因组学与应用生物学，2015，34(9)：1912-1916

17. 胡祖权，李和平，吴平，廖玉才，张静柏*. 抗镰刀菌单链抗体在大肠杆菌中可溶性表达条件的研究. 生物技术通报，2015，31(9)：238-243

其他作者文章

1. Yuan, Q.-S., Yang, P., Liu, Y.-K., Tabl, K.-M., Guo, M.-W., Zhang, J.-B., Wu, A.-B., Liao, Y.-C., Huang, T., He, W.-J. Iturin and fengycin lipopeptides inhibit pathogenic Fusarium by targeting multiple components of the cell membrane and their regulative effects in wheat. Journal of Integrative Plant Biology, 2025, 67: 2184–2197.

2. Gong, A.-D., Song, M.-G., Zhang, J.-B. Current strategies in controlling Aspergillus flavus and aflatoxins in grains during storage: A Review. Sustainability, 2024, 16: 3171. https://doi.org/10.3390/su16083171

3. Gong, A.-D., Song, M.-G., Wang, H.-L. , Wang, G.-Z. , Wang, J.-H., Zhang, J.-B. Inhibitory effect of volatile organic compounds from bacillus flexus tr-1 against Aspergillus flavus and aflatoxins in grains during storage. BioControl, 2023, 68: 181–190.

4. Huang, T., He, W.-J., Li, C., Zhang J.-B., Liao Y.-C., Song B., Yang P. Transcriptome-wide analyses of RNA m6A methylation in hexaploid wheat reveal its roles in mRNA translation regulation. Frontiers in Plant Science, 2022, 13: 917335

5. Liu, G., Zuo, D.-Y., Yang, P., He, W.-J., Yang, Z., Zhang, J.-B., Wu, A.-B., Yi, S.-Y., Li, H.-P., Huang, T*., Liao, Y.-C*. A Novel Deoxynivalenol-Activated Wheat Arl6ip4 Gene Encodes an Antifungal Peptide with Deoxynivalenol Affinity and Protects Plants against Fusarium Pathogens and Mycotoxins. Journal of Fungi, 2021, 7: 941.

6. Wang, L., Yan Z., Zhou H.-Y., Fan Y.-Y., Wang C., Zhang, J.-B., Liao, Y.-C., Wu, A.-B. Validation of LC-MS/MS coupled with a chiral column for the determination of 3- or 15-acetyl deoxynivalenol mycotoxins from Fusarium graminearum in wheat. Toxins, 2021, 13(9): 659.

7. Guo, M.-W., Yang, P., Zhang, J.-B., Liu, G., Yuan, Q.-S, He, W.-J., Nian, J.-N., Yi, S.-Y, Huang, T., Liao, Y.-C. Expression of microRNA-like RNA-2 (Fgmil-2) and bioH1 from a single transcript in Fusarium graminearum are inversely correlated to regulate biotin synthesis during vegetative growth and host infection, Molecular Plant Pathology, 2019, 20(11): 1574-1581.

8. Song, X.-S., Xing, S., Li, H.-P., Zhang, J.-B., Qu, B., Jiang, J.-H., Fan, C., Yang, P., Liu, J.-L., Hu, Z.-Q., Xue, S., Liao, Y.-C*. An antibody that confers plant disease resistance targets a membrane-bound glyoxal oxidase in Fusarium. New Phytologist, 2016, 210(3): 997-1010.

9. He, W.-J., Yuan, Q.-S, Zhang, Y.-B., Guo, M.-W., Gong, A,-D.,Zhang, J.-B., Wu, A.-B., Huang, T., Qu, B., Li, H.-P., Liao, Y.-C. Aerobic de-Epoxydation of trichothecene mycotoxins by a soil bacterial consortium isolated using in situ soil enrichment. Toxins, 2016, 8, 277.

10. Cheng, W., Song, X.-S., Li, H.-P., Cao, L.-H., Sun, K., Qiu, X.-L., Xu, Y.-B., Yang, P., Huang, T., Zhang, J.-B., Qu, B., Liao, Y.-C. Host-induced gene silencing of an essential chitin synthase gene confers durable resistance to Fusarium head blight and seedling blight in wheat. Plant Biotechnology Journal, 2015, 13, 1335-1345.

11. Cheng, W., Li, H.-P., Zhang, J.-B., Du, H.-J., Wei, Q.-Y., Huang, T., Yang, P., Kong, X.-W., Liao, Y.-C. Tissue-specific and pathogen-inducible expression of a fusion protein containing a Fusarium-specific antibody and a fungal chitinase protects wheat against Fusarium pathogens and mycotoxins. Plant Biotechnology Journal, 2015, 13: 664-674.

12. Gong, A,-D., Li, H.-P., Shen, L., Zhang, J.-B., Wu, A.-B., He, W.-J., Yuan, Q.-S., He, J.-D., Liao, Y.-C. The Shewanella algae strain YM8 produces volatiles with strong inhibition activity against Aspergillus pathogens and aflatoxins. Frontiers in Microbiology, 2015, Oct 6. doi: 10.3389/fmicb.2015.01091.

13. Hu, Z.-Q., Li, H.-P., Wu, P., Li, Y.-B., Zhou, Z.-Q., Zhang, J.-B., Liu, J.-L., Liao, Y.-C*. An affinity improved single-chain antibody from phage display of a library derived from monoclonal antibodies detects fumonisins by immunoassay. Analytica Chimica Acta, 2015, 867: 74-82.

14. Gong, A.-D., Li, H.-P., Yuan, Q.-S., Song, X.-S., Yao, W., He, W.-J., Zhang, J.-B., Liao, Y.-C. Antagonistic mechanism of iturin A and plipastatin A from Bacillus amyloliquefaciens S76-3 from wheat spikes against Fusarium graminearum. PLoS ONE, 2015 Feb 17;10(2): e0116871.

15. Song, X.-S., Li, H.-P., Zhang, J.-B., Song, B., Huang, T., Du, X.-M., Gong, A.-D., Liu, Y.-K., Feng, Y.-N., Agboola, R.S., Liao, Y.-C. Trehalose 6-phosphate phosphatase is required for development, virulence and mycotoxin biosynthesis apart from trehalose biosynthesis in Fusarium graminearum. Fungal Genetics and Biology, 2014, 63: 24-41.

16. Wang, J.-H., Li, H.-P., Zhang, J.-B., Wang, B.-T., Liao, Y.-C. First report of Fusarium maize ear rot caused by Fusarium kyushuense in China . Plant Disease, 2014, 98: 279-280. DOI: 10.1094/PDIS-05-13-0558-PDN.

17. Xue, S., Li, H.-P., Zhang, J.-B., Liu, J.-L., Hu, Z.-Q., Gong, A.-D., Huang, T., Liao, Y.-C. Chicken single-chain antibody fused to alkaline phosphatase detects Aspergillus pathogens and their presence in natural samples by direct sandwich enzyme-linked immunosorbent assay. Analytical Chemistry, 2013, 85, 10992-10999.

18. Song, B., Li, H.-P., Zhang, J.-B., Wang, J.-H., Gong, A.-D., Song, X.-S., Chen T., Liao, Y.-C. Type II myosin gene in Fusarium graminearum is required for septation, development, mycotoxin biosynthesis and pathogenicity. Fungal Genetics and Biology, 2013, 54: 60-70.

19. Hu, Z.-Q., Li, H.-P., Zhang, J.-B., Huang, T., Liu, J.-L., Xue, S., Wu, A.-B., Liao, Y.-C. A phage-displayed chicken single-chain antibody fused to alkaline phosphatase detects Fusarium pathogens and their presence in cereal grains. Analytica Chimica Acta, 2013, 764: 84-92.

20. Gao, C.-S., Kou, X.-J., Li, H.-P., Zhang, J.-B., Saad, A. Sefyan I., Liao, Y.-C. Inverse effects of Arabidopsis NPR1 gene on fusarium seedling blight and fusarium head blight in transgenic wheat. Plant Pathology, 2013, 62: 383-392.

21. Liu, Z.-W., Li, H.-P., Cheng, W., Yang, P., Zhang, J.-B., Gong, A.-D., Feng, Y.-N., Fernando, W. G. D., Liao, Y.-C. Enhanced overall resistance to Fusarium seedling blight and Fusarium head blight in transgenic wheat by co-expression of anti-fungal peptides. European Journal of Plant Pathology, 2012, 134: 721-732.

22. Hu, Z.-Q., Liu, J. L., Li, H.-P., Xing, S., Xue, S., Zhang, J.-B., Wang, J.-H., Nölke, G., Liao, Y.-C. Generation of a highly reactive chicken-derived single-chain variable fragment against Fusarium verticillioides by phage display. International Journal of Molecular Sciences,2012, 13, 7038-7056.

23. Ndoye, M., Zhang, J.-B., Wang, J.-H., Gong, A.-D, Qu, B., Li, H.-P., Li, S.-J, Liao, Y.-C. Nivalenol and 15-acetyldeoxynivalenol chemotypes of Fusarium graminearum clade species are prevalent on maize throughout China . Journal of Phytopathology, 2012, 160: 519-524.

24. Wang, J.-H., Zhang, J.-B., Chen, F.- F., Li, H.-P., Ndoye M., Liao, Y.-C. A multiplex PCR assay for genetic chemotyping of toxigenic Fusarium graminearum and wheat grains for 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol and nivalenol mycotoxins. Journal of Food, Agriculture and Environment. 2012, 10: 505-511.

25. Liu, J.-L., Hu, Z.-Q., Xing, S., Xue, S., Li, H.-P., Zhang, J.-B., Liao, Y.-C. Attainment of 15-fold higher affinity of a Fusarium-specific single-chain antibody by directed molecular evolution coupled to phage display. Molecular Biotechnology, 2012, 52: 111-122.

26. Liu, G., Han, Z., Nie, D., Yang, J., Zhao, Z. H., Zhang, J.-B., Li, H.P., Liao, Y. C., Song, S., Saeger, S. D., Wu, A. B. Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Food Control, 2012, 27: 200-205.

27. Han, Z., Zhao, Z.-Y., Song, S.-Q., Liu, G., Shi, J.-X., Zhang, J.-B., Liao, Y.-C., Zhang, D.-B., Saeger, S. D., Wu, A.-B. Establishment of a model isotope dilution LC-MS/MS method revealing kinetics and distribution of co-occurring mycotoxins in rat. Analytical Methods, 2012, 4, 3708–3717.

28. Wang, J.-H., Ndoye, M., Zhang, J.-B., Li, H.-P., Liao, Y.-C. Population structure and genetic diversity of the Fusarium graminearum species complex. Toxins, 2011, 3, 1020-1037.

29. Xu, Y.-B., Li, H.-P., Zhang, J.-B., Song, B., Chen, F.-F., Duan, X.-J., Xu, H.-Q., Liao, Y.-C. Disruption of the chitin synthase gene Chs1 from Fusarium asiaticum results in an altered structure of cell walls and reduced virulence. Fungal Genetics and Biology, 2010, 47: 205-215.

30. Wang, J.-H., Li, H.-P., Qu, B., Zhang, J.-B., Huang, T., Chen, F.-F., Liao, Y.-C. Development of a generic PCR detection of 3-acetyldeoxynivalenol-, 15-acetyldeoxynivalenol- and nivalenol-chemotypes of Fusarium graminearum clade. International Journal of Molecular Sciences, 2008, 9:2495-2504.

教材与著作

1. 《普通遗传学实验》参编，2015，高等教育出版社

2. 《遗传学》（第三版），参编，2015，科学出版社

3. 《植物生物技术》（第二版），参编，2012，科学出版社